503 BRAF-V600 Mutation discordance in Primary and Metastatic Melanoma
نویسندگان
چکیده
منابع مشابه
Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation
Plasmacytoid melanoma is an unusual variant of malignant melanoma. The plasmacytoid morphology can be found in a variety of other malignancies including carcinomas, plasma cell neoplasms, lymphoproliferative disorders, and sarcomas. The authors report a rare case of plasmacytoid amelanotic malignant melanoma in a 78-year-old man presenting with an enlarging palpable, erythematous mass on his le...
متن کاملThe significance of BRAF V600E mutation status discordance between primary cutaneous melanoma and brain metastases
To compare BRAF V600E status of primarymelanoma and brainmetastases to assess for discordance by cross-sectional study, and to evaluate clinical implications on BRAF inhibitor therapy. Brain metastases are common in patients with advanced melanoma. Between 40% and 60% of melanomas demonstrate BRAF mutations, BRAF V600E being most common. Selective BRAF inhibitor therapy has shown improvement in...
متن کاملBRAF V600 mutations and pathological features in Japanese melanoma patients
Ultraviolet radiation is a risk factor for BRAF V600 mutations frequently found in melanomas that cause constitutive BRAF activation. Primary sites of melanoma and the frequency of BRAF mutations might differ between races. Melanoma is rare in Japan (1500-2000 cases/year compared with 132 000/year worldwide) and the frequency and distribution of BRAF V600 mutations are unknown. We aimed to inve...
متن کاملSkin toxicity in BRAF(V600) mutated metastatic cutaneous melanoma patients treated with vemurafenib
INTRODUCTION The use of orally available BRAF kinase inhibitor - vemurafenib is associated with numerous adverse skin reactions. AIM To assess the safety and early side effects of vemurafenib treatment in the unselected group of patients treated at the outpatient clinic, in particular the assessment of the incidence of skin cancer. MATERIAL AND METHODS We carried out a systematic study of p...
متن کاملCerebrospinal fluid concentrations of vemurafenib in patients treated for brain metastatic BRAF-V600 mutated melanoma.
Anti-BRAF agents, including vemurafenib, have modified the prognosis for patients with melanoma. However, a difference can still be observed between extracerebral and cerebral responses. The aim of this study was to investigate the diffusion of vemurafenib in cerebrospinal fluid (CSF) from patients treated for brain metastatic BRAF-V600 mutated melanoma. Six patients treated with vemurafenib 96...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.06.525